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Title(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 6, Page 562-567, Year 2015
Publish dateMar 6, 2015 (structure data deposition date)
AuthorsChoi, H.S. / Rucker, P.V. / Wang, Z. / Fan, Y. / Albaugh, P. / Chopiuk, G. / Gessier, F. / Sun, F. / Adrian, F. / Liu, G. ...Choi, H.S. / Rucker, P.V. / Wang, Z. / Fan, Y. / Albaugh, P. / Chopiuk, G. / Gessier, F. / Sun, F. / Adrian, F. / Liu, G. / Hood, T. / Li, N. / Jia, Y. / Che, J. / McCormack, S. / Li, A. / Li, J. / Steffy, A. / Culazzo, A. / Tompkins, C. / Phung, V. / Kreusch, A. / Lu, M. / Hu, B. / Chaudhary, A. / Prashad, M. / Tuntland, T. / Liu, B. / Harris, J. / Seidel, H.M. / Loren, J. / Molteni, V.
External linksAcs Med. Chem. Lett. / PubMed:26005534
MethodsX-ray diffraction
Resolution2 - 2.1012 Å
Structure data

PDB-4ymj:
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4yne:
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.0229 Å

PDB-4yps:
(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.1012 Å

Chemicals

ChemComp-4EJ:
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-4EK:
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine

ChemComp-SO4:
SULFATE ION

ChemComp-4F6:
4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase inhibitor / Kinase / TRK / Inhibitor / Oncology / Transferase-Transferase inhibitor complex / Transfease/Transferase Inhibitor / TrkA / Inhibitor complex. / Transfease-Transferase Inhibitor complex

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