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Title | (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 6, Page 562-567, Year 2015 |
Publish date | Mar 6, 2015 (structure data deposition date) |
![]() | Choi, H.S. / Rucker, P.V. / Wang, Z. / Fan, Y. / Albaugh, P. / Chopiuk, G. / Gessier, F. / Sun, F. / Adrian, F. / Liu, G. ...Choi, H.S. / Rucker, P.V. / Wang, Z. / Fan, Y. / Albaugh, P. / Chopiuk, G. / Gessier, F. / Sun, F. / Adrian, F. / Liu, G. / Hood, T. / Li, N. / Jia, Y. / Che, J. / McCormack, S. / Li, A. / Li, J. / Steffy, A. / Culazzo, A. / Tompkins, C. / Phung, V. / Kreusch, A. / Lu, M. / Hu, B. / Chaudhary, A. / Prashad, M. / Tuntland, T. / Liu, B. / Harris, J. / Seidel, H.M. / Loren, J. / Molteni, V. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.1012 Å |
Structure data | ![]() PDB-4ymj: ![]() PDB-4yne: ![]() PDB-4yps: |
Chemicals | ![]() ChemComp-4EJ: ![]() ChemComp-GOL: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-4EK: ![]() ChemComp-SO4: ![]() ChemComp-4F6: |
Source |
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![]() | Transferase/Transferase inhibitor / Kinase / TRK / Inhibitor / Oncology / Transferase-Transferase inhibitor complex / Transfease/Transferase Inhibitor / TrkA / Inhibitor complex. / Transfease-Transferase Inhibitor complex |