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Structure paper

TitleStructure-guided residence time optimization of a dabigatran reversal agent.
Journal, issue, pagesMabs, Vol. 7, Page 871-880, Year 2015
Publish dateFeb 26, 2015 (structure data deposition date)
AuthorsSchiele, F. / van Ryn, J. / Litzenburger, T. / Ritter, M. / Seeliger, D. / Nar, H.
External linksMabs / PubMed:26047352
MethodsX-ray diffraction
Resolution1.76 - 2.31 Å
Structure data

PDB-4ygv:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-4yhi:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4yhk:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-4yhl:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-4yhm:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-4yhn:
Dabigatran Reversal Agent
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-4yho:
Reversal Agent for Dabigatran
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-4CC:
N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / Dabigatran / Pradaxa / Antidote / Reversal Agent / antibodies

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