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| Title | The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. |
|---|---|
| Journal, issue, pages | Acta Crystallogr. ,Sect. D, Vol. 71, Page 1555-1563, Year 2015 |
| Publish date | Oct 30, 2014 (structure data deposition date) |
Authors | Klima, M. / Baumlova, A. / Chalupska, D. / Hrebabecky, H. / Dejmek, M. / Nencka, R. / Boura, E. |
External links | Acta Crystallogr. ,Sect. D / PubMed:26143926 |
| Methods | X-ray diffraction |
| Resolution | 1.9 - 2.58 Å |
| Structure data | ![]() PDB-4wtv: ![]() PDB-4yc4: |
| Chemicals | ![]() ChemComp-ATP: ![]() ChemComp-HOH: ![]() ChemComp-M59: ![]() ChemComp-ADP: |
| Source |
|
Keywords | TRANSFERASE / lipid kinase / phosphatidyl inositol / hydrolase / Kinase / Complex / Inhibitor |
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