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TitleLipid and Carbohydrate Modifications of alpha-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 17206-17217, Year 2015
Publish dateFeb 6, 2015 (structure data deposition date)
AuthorsBirkholz, A. / Nemcovic, M. / Yu, E.D. / Girardi, E. / Wang, J. / Khurana, A. / Pauwels, N. / Farber, E. / Chitale, S. / Franck, R.W. ...Birkholz, A. / Nemcovic, M. / Yu, E.D. / Girardi, E. / Wang, J. / Khurana, A. / Pauwels, N. / Farber, E. / Chitale, S. / Franck, R.W. / Tsuji, M. / Howell, A. / Van Calenbergh, S. / Kronenberg, M. / Zajonc, D.M.
External linksJ. Biol. Chem. / PubMed:26018083
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4y16:
Crystal structure of the mCD1d/NC-aGC/iNKTCR ternary complex
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-48G:
N-[(2S,3S,4R)-3,4-dihydroxy-1-{[6-O-(naphthalen-1-ylcarbamoyl)-alpha-D-galactopyranosyl]oxy}octadecan-2-yl]hexacosanamide

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / MHC-fold / Ig-fold / glycolipid antigen presentation / T cell receptor

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