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TitleRational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 54, Page 13462-13465, Year 2015
Publish dateFeb 6, 2015 (structure data deposition date)
AuthorsZhang, L. / Mori, T. / Zheng, Q. / Awakawa, T. / Yan, Y. / Liu, W. / Abe, I.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:26356484
MethodsX-ray diffraction
Resolution1.5 - 2.203 Å
Structure data

PDB-4y0k:
Structure of crotonyl-CoA carboxylase/reductase AntE in complex with NADP
Method: X-RAY DIFFRACTION / Resolution: 2.203 Å

PDB-4y1b:
Structure of crotonyl-CoA carboxylase/reductase AntE V350A in complex with NADP
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

Source
  • streptomyces sp. nrrl 2288 (bacteria)
KeywordsOXIDOREDUCTASE / TRANSFERASE / ANTIMYCIN BIOSYNTHESIS / CARBOXYLASE

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