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-Structure paper
Title | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. |
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Journal, issue, pages | Chemmedchem, Vol. 10, Page 1989-2003, Year 2015 |
Publish date | Feb 4, 2015 (structure data deposition date) |
![]() | Ruiz, F.X. / Cousido-Siah, A. / Porte, S. / Dominguez, M. / Crespo, I. / Rechlin, C. / Mitschler, A. / de Lera, A.R. / Martin, M.J. / de la Fuente, J.A. ...Ruiz, F.X. / Cousido-Siah, A. / Porte, S. / Dominguez, M. / Crespo, I. / Rechlin, C. / Mitschler, A. / de Lera, A.R. / Martin, M.J. / de la Fuente, J.A. / Klebe, G. / Pares, X. / Farres, J. / Podjarny, A. |
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Methods | X-ray diffraction |
Resolution | 1 - 2.45 Å |
Structure data | ![]() PDB-4xzh: ![]() PDB-4xzi: ![]() PDB-4xzl: ![]() PDB-4xzm: ![]() PDB-4xzn: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-48I: ![]() ChemComp-HOH: ![]() ChemComp-F49: ![]() ChemComp-EDO: |
Source |
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![]() | OXIDOREDUCTASE / TIM barrel / Aldose reductase / diabetes / Halogenated compound / Cytosolic / Aldo-keto reductase 1B10 / Aldo-Keto Reductase / holoenzyme |