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Structure paper

TitleStructural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 138, Page 2389-2398, Year 2016
Publish dateJan 19, 2015 (structure data deposition date)
AuthorsLiu, M.S. / Tsai, H.Y. / Liu, X.X. / Ho, M.C. / Wu, W.J. / Tsai, M.D.
External linksJ. Am. Chem. Soc. / PubMed:26836966
MethodsX-ray diffraction
Resolution2.36 - 3.36 Å
Structure data

PDB-4xq8:
Human DNA polymerase lambda- MgdATP binary complex and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.798 Å

PDB-4xrh:
Human DNA polymerase lambda- MgdTTP binary and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-5ca7:
Human DNA polymerase lambda- MgdGTP binary and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.522 Å

PDB-5cb1:
Apo enzyme of human Polymerase lambda
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-5chg:
Human DNA polymerase lambda L431A mutant- MgdGTP binary and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5cj7:
Human DNA polymerase lambda L431A mutant- MgdTTP binary and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.901 Å

PDB-5cp2:
Human DNA polymerase lambda L431A mutant- Apoenzyme and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-5cr0:
Human DNA polymerase lambda L431A mutant- MgdCTP binary and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-5cwr:
Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5ddm:
Human DNA polymerase lambda- Apoenzyme and complex with 6 paired DNA
Method: X-RAY DIFFRACTION / Resolution: 2.802 Å

PDB-5ddy:
Binary complex of human Polymerase lambda with dCTP
Method: X-RAY DIFFRACTION / Resolution: 3.36 Å

PDB-5dkw:
Ternary crystal structure of polymerase lambda with a GA mispair at the primer terminus with Ca2+ in the active
Method: X-RAY DIFFRACTION / Resolution: 2.689 Å

Chemicals

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TTP:
THYMIDINE-5'-TRIPHOSPHATE

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-SO4:
SULFATE ION

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-MN:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / complex / MgdATP / TRANSFERASE-DNA complex / DNA polymerase lambda / TRANSFERASE / Polymerase lambda

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