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| Title | Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 58, Page 1776-1794, Year 2015 |
| Publish date | Dec 15, 2014 (structure data deposition date) |
 Authors | Monn, J.A. / Prieto, L. / Taboada, L. / Pedregal, C. / Hao, J. / Reinhard, M.R. / Henry, S.S. / Goldsmith, P.J. / Beadle, C.D. / Walton, L. ...Monn, J.A. / Prieto, L. / Taboada, L. / Pedregal, C. / Hao, J. / Reinhard, M.R. / Henry, S.S. / Goldsmith, P.J. / Beadle, C.D. / Walton, L. / Man, T. / Rudyk, H. / Clark, B. / Tupper, D. / Baker, S.R. / Lamas, C. / Montero, C. / Marcos, A. / Blanco, J. / Bures, M. / Clawson, D.K. / Atwell, S. / Lu, F. / Wang, J. / Russell, M. / Heinz, B.A. / Wang, X. / Carter, J.H. / Xiang, C. / Catlow, J.T. / Swanson, S. / Sanger, H. / Broad, L.M. / Johnson, M.P. / Knopp, K.L. / Simmons, R.M. / Johnson, B.G. / Shaw, D.B. / McKinzie, D.L. |
 External links | J. Med. Chem. / PubMed:25602126 |
| Methods | X-ray diffraction |
| Resolution | 2.21 - 2.35 Å |
| Structure data |  PDB-4xaq:  PDB-4xar:  PDB-4xas: |
| Chemicals |  ChemComp-40F:  ChemComp-SO4:  ChemComp-CL:  ChemComp-HOH:  ChemComp-IOD:  ChemComp-40H: |
| Source |
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 Keywords | SIGNALING PROTEIN / mGluR2 mGluR3 / mGluR2 mGluR3 ECD / mGluR2 ECD |
homo sapiens (human)