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-Structure paper
Title | Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 145-150, Year 2016 |
Publish date | Nov 26, 2014 (structure data deposition date) |
Authors | Taylor, A.M. / Vaswani, R.G. / Gehling, V.S. / Hewitt, M.C. / Leblanc, Y. / Audia, J.E. / Bellon, S. / Cummings, R.T. / Cote, A. / Harmange, J.C. ...Taylor, A.M. / Vaswani, R.G. / Gehling, V.S. / Hewitt, M.C. / Leblanc, Y. / Audia, J.E. / Bellon, S. / Cummings, R.T. / Cote, A. / Harmange, J.C. / Jayaram, H. / Joshi, S. / Lora, J.M. / Mertz, J.A. / Neiss, A. / Pardo, E. / Nasveschuk, C.G. / Poy, F. / Sandy, P. / Setser, J.W. / Sims, R.J. / Tang, Y. / Albrecht, B.K. |
External links | Acs Med. Chem. Lett. / PubMed:26985289 |
Methods | X-ray diffraction |
Resolution | 1.06 - 1.399 Å |
Structure data | PDB-4x2i: PDB-4z1q: PDB-4z1s: |
Chemicals | ChemComp-FMT: ChemComp-3X0: ChemComp-HOH: ChemComp-558: ChemComp-559: |
Source |
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Keywords | SIGNALING PROTEIN / BET / CPI-13 / TRANSCRIPTION / bromodomain |