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Structure paper

TitleStereochemical control of nucleosome targeting by platinum-intercalator antitumor agents.
Journal, issue, pagesNucleic Acids Res., Vol. 43, Page 5284-5296, Year 2015
Publish dateOct 31, 2014 (structure data deposition date)
AuthorsChua, E.Y. / Davey, G.E. / Chin, C.F. / Droge, P. / Ang, W.H. / Davey, C.A.
External linksNucleic Acids Res. / PubMed:25916851
MethodsX-ray diffraction
Resolution2.45 - 2.6 Å
Structure data

PDB-4wu8:
Structure of trPtNAP-NCP145
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4wu9:
Structure of cisPtNAP-NCP145
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CX3:
[2-(3-{bis[2-(amino-kappaN)ethyl]amino-kappaN}propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dionato(2-)]platinum(1+)

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CX8:
[2-{3-[(2-{[2-(amino-kappaN)ethyl]amino-kappaN}ethyl)amino-kappaN]propyl}-1H-benzo[de]isoquinoline-1,3(2H)-dionato(3-)]platinum

Source
  • xenopus laevis (African clawed frog)
  • synthetic construct (others)
KeywordsSTRUCTURAL PROTEIN/DNA / STRUCTURAL PROTEIN-DNA complex / Nucleosome / platinum drug targeting

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