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-Structure paper
Title | The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 834-840, Year 2015 |
Publish date | Oct 31, 2014 (structure data deposition date) |
![]() | Wang, H.L. / Cee, V.J. / Chavez, F. / Lanman, B.A. / Reed, A.B. / Wu, B. / Guerrero, N. / Lipford, J.R. / Sastri, C. / Winston, J. ...Wang, H.L. / Cee, V.J. / Chavez, F. / Lanman, B.A. / Reed, A.B. / Wu, B. / Guerrero, N. / Lipford, J.R. / Sastri, C. / Winston, J. / Andrews, K.L. / Huang, X. / Lee, M.R. / Mohr, C. / Xu, Y. / Zhou, Y. / Tasker, A.S. |
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Methods | X-ray diffraction |
Resolution | 2.2 - 3.05 Å |
Structure data | ![]() PDB-4rpv: ![]() PDB-4wrs: |
Chemicals | ![]() ChemComp-3UR: ![]() ChemComp-GOL: ![]() ChemComp-3U1: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Pim1 / kinase / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / serine/threonine protein kinase |