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Structure paper

TitleCrystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 22, Page 37-43, Year 2015
Publish dateOct 15, 2014 (structure data deposition date)
AuthorsThevakumaran, N. / Lavoie, H. / Critton, D.A. / Tebben, A. / Marinier, A. / Sicheri, F. / Therrien, M.
External linksNat. Struct. Mol. Biol. / PubMed:25437913
MethodsX-ray diffraction
Resolution2.83 Å
Structure data

PDB-4wo5:
Crystal structure of a BRAF kinase domain monomer
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

Chemicals

ChemComp-324:
N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE Inhibitor / Kinase / Monomer / Inhibitor / Complex / TRANSFERASE-TRANSFERASE Inhibitor complex

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