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Structure paper

TitleGene regulation. Structural basis for microRNA targeting.
Journal, issue, pagesScience, Vol. 346, Page 608-613, Year 2014
Publish dateAug 18, 2014 (structure data deposition date)
AuthorsSchirle, N.T. / Sheu-Gruttadauria, J. / MacRae, I.J.
External linksScience / PubMed:25359968
MethodsX-ray diffraction
Resolution1.802 - 3.101 Å
Structure data

PDB-4w5n:
The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4w5o:
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9
Method: X-RAY DIFFRACTION / Resolution: 1.802 Å

PDB-4w5q:
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8
Method: X-RAY DIFFRACTION / Resolution: 3.101 Å

PDB-4w5r:
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4w5t:
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/RNA / AGO2 / RNase / RNAi / RNA / HYDROLASE-RNA complex / Guide / Target / Seed / microRNA

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