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-Structure paper
Title | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. |
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Journal, issue, pages | Mol. Cell, Vol. 56, Page 531-540, Year 2014 |
Publish date | Sep 12, 2014 (structure data deposition date) |
![]() | Polikanov, Y.S. / Osterman, I.A. / Szal, T. / Tashlitsky, V.N. / Serebryakova, M.V. / Kusochek, P. / Bulkley, D. / Malanicheva, I.A. / Efimenko, T.A. / Efremenkova, O.V. ...Polikanov, Y.S. / Osterman, I.A. / Szal, T. / Tashlitsky, V.N. / Serebryakova, M.V. / Kusochek, P. / Bulkley, D. / Malanicheva, I.A. / Efimenko, T.A. / Efremenkova, O.V. / Konevega, A.L. / Shaw, K.J. / Bogdanov, A.A. / Rodnina, M.V. / Dontsova, O.A. / Mankin, A.S. / Steitz, T.A. / Sergiev, P.V. |
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Methods | X-ray diffraction |
Resolution | 2.4 - 2.7 Å |
Structure data | ![]() PDB-4w2f: ![]() PDB-4w2g: ![]() PDB-4w2h: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-UAM: ![]() ChemComp-SF4: ![]() ChemComp-ZN: ![]() ChemComp-K: ![]() ChemComp-HOH: ![]() ChemComp-PCY: |
Source |
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![]() | RIBOSOME/ANTIBIOTIC / Amicoumacin / antibiotic / 70S ribosome / inhibition of translation / translocation inhibitor / 30S subunit with amicoumacin / mRNA / deacylated A- / P- / and E-site tRNAs of the 1st 70S ribosome in the ASU / Functional complex of bacterial 70S ribosome with antibiotic amicoumacin / RIBOSOME-ANTIBIOTIC complex / Pactamycin / initiation inhibitor / 30S subunit with pactamycin (soaked) / Functional complex of bacterial 70S ribosome with antibiotic pactamycin (compact conformation) / 50S subunit of the 1st 70S ribosome in the ASU / 30S subunit with pactamycin (co-crystallized) / deacylated P-site tRNA / and E-site tRNA acceptor stem of the 1st 70S ribosome in the ASU / Functional complex of bacterial 70S ribosome with antibiotic pactamycin (extended conformation) |