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-Structure paper
Title | The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study |
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Journal, issue, pages | Ebiomedicine, Vol. 2, Page 194-, Year 2015 |
Publish date | Aug 15, 2014 (structure data deposition date) |
![]() | Bunney, T. / Wan, S. / Thiyagarajan, N. / Sutto, L. / Williams, S.V. / Ashford, P. / Koss, H. / Knowles, M.A. / Gervasio, F.L. / Coveney, P.V. / Katan, M. |
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Methods | X-ray diffraction |
Resolution | 1.957 - 2.305 Å |
Structure data | ![]() PDB-4uwy: ![]() PDB-5am6: ![]() PDB-5am7: |
Chemicals | ![]() ChemComp-PEG: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-38O: |
Source |
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![]() | TRANSFERASE / INHIBITOR / DRUG / CANCER / FGF / RECEPTORS / GROWTH FACTORS / SIGNALLING / FGFR / GROWTH FACTOR / DOVITINIB / TKI258 / KINASE / GATEKEEPER / GATE KEEPER |