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TitleDiscovery of 9-(1-Phenoxyethyl)-2-Morpholino-4-Oxo-Pyrido[1, 2-A]Pyrimidine-7-Carboxamides as Oral Pi3Kbeta Inhibitors, Useful as Antiplatelet Agents.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 3936-, Year 2014
Publish dateJun 30, 2014 (structure data deposition date)
AuthorsGiordanetto, F. / Barlaam, B. / Berglund, S. / Edman, K. / Karlsson, O. / Lindberg, J. / Nylander, S. / Inghardt, T.
External linksBioorg. Med. Chem. Lett. / PubMed:25042253
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-4urk:
PI3Kg in complex with AZD6482
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-A82:
2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / LIPID KINASE

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