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Title | Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule. |
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Journal, issue, pages | J. Biol. Chem., Vol. 290, Page 762-, Year 2015 |
Publish date | May 22, 2014 (structure data deposition date) |
![]() | Deng, G. / Shen, J. / Yin, M. / Mcmanus, J. / Mathieu, M. / Gee, P. / He, T. / Shi, C. / Bedel, O. / Mclean, L.R. ...Deng, G. / Shen, J. / Yin, M. / Mcmanus, J. / Mathieu, M. / Gee, P. / He, T. / Shi, C. / Bedel, O. / Mclean, L.R. / Le-Strat, F. / Zhang, Y. / Marquette, J. / Gao, Q. / Zhang, B. / Rak, A. / Hoffmann, D. / Rooney, E. / Vassort, A. / Englaro, W. / Li, Y. / Patel, V. / Adrian, F. / Gross, S. / Wiederschain, D. / Cheng, H. / Licht, S. |
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Methods | X-ray diffraction |
Resolution | 1.88 - 2.07 Å |
Structure data | ![]() PDB-4umx: ![]() PDB-4umy: |
Chemicals | ![]() ChemComp-VVS: ![]() ChemComp-NAP: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-SO4: |
Source |
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![]() | OXIDOREDUCTASE / ISOCITRATE DEHYDROGENASE INHIBITOR |