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-Structure paper
Title | Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors |
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Journal, issue, pages | To be published |
Publish date | Jul 28, 2014 (structure data deposition date) |
Authors | Elliot, R.J. / Jarvis, A. / Rajasekaran, M.B. / Menon, M. / Bowers, L. / Boffey, R. / Bayford, M. / Firth-Clark, S. / Beevers, R. / Aquil, R. ...Elliot, R.J. / Jarvis, A. / Rajasekaran, M.B. / Menon, M. / Bowers, L. / Boffey, R. / Bayford, M. / Firth-Clark, S. / Beevers, R. / Aquil, R. / Kirton, S.B. / Niculescu-Duvaz, D. / Fish, L. / Lopes, F. / McLeary, R. / Trindade, I. / Vendrell, E. / Munkonge, F. / Porter, R. / Perrior, T. / Springer, C. / Oliver, A.W. / Pearl, L.H. / Ashworth, A. / Lord, C.J. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.37 Å |
Structure data | PDB-4u6a: |
Chemicals | ChemComp-ZN: ChemComp-3DN: ChemComp-GOL: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Inhibitor / WNT signalling |