| タイトル | Synergy of streptogramin antibiotics occurs independently of their effects on translation. |
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| ジャーナル・号・ページ | Antimicrob. Agents Chemother., Vol. 58, Page 5269-5279, Year 2014 |
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| 掲載日 | 2014年7月16日 (構造データの登録日) |
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著者 | Noeske, J. / Huang, J. / Olivier, N.B. / Giacobbe, R.A. / Zambrowski, M. / Cate, J.H. |
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リンク | Antimicrob. Agents Chemother. / PubMed:24957822 |
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| 手法 | X線回折 |
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| 解像度 | 2.8 - 3 Å |
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| 構造データ | PDB-4u1u: Crystal structure of the E. coli ribosome bound to quinupristin. 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-4u1v: Crystal structure of the E. coli ribosome bound to linopristin. 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4u20: Crystal structure of the E. coli ribosome bound to flopristin. 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4u24: Crystal structure of the E. coli ribosome bound to dalfopristin. 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4u25: Crystal structure of the E. coli ribosome bound to virginiamycin M1. 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4u26: Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4u27: Crystal structure of the E. coli ribosome bound to flopristin and linopristin. 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å |
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| 化合物 | ChemComp-DOL: 5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE / 抗生剤*YM
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| 由来 |  escherichia coli str. k-12 substr. mds42 (大腸菌) escherichia coli (大腸菌) thermus thermophilus (バクテリア)- synthetic construct (人工物)
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キーワード | RIBOSOME / Protein biosynthesis / RNA / transfer / exit / peptidyl / 30S / 70S / 16S / ribosomal subunit / antibiotic / streptogramin |
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