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TitleStructure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 4444-4449, Year 2014
Publish dateJul 8, 2014 (structure data deposition date)
AuthorsParsy, C. / Alexandre, F.R. / Brandt, G. / Caillet, C. / Cappelle, S. / Chaves, D. / Convard, T. / Derock, M. / Gloux, D. / Griffon, Y. ...Parsy, C. / Alexandre, F.R. / Brandt, G. / Caillet, C. / Cappelle, S. / Chaves, D. / Convard, T. / Derock, M. / Gloux, D. / Griffon, Y. / Lallos, L. / Leroy, F. / Liuzzi, M. / Loi, A.G. / Moulat, L. / Musiu, C. / Rahali, H. / Roques, V. / Seifer, M. / Standring, D. / Surleraux, D.
External linksBioorg. Med. Chem. Lett. / PubMed:25155387
MethodsX-ray diffraction
Resolution2.84 Å
Structure data

PDB-4tyd:
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-3EO:
(4R,6S,7Z,15S,17S)-17-[({7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)methyl]-13-methyl-N-[(1-methylcyclopropyl)sulfonyl]-2,14-dioxo-1,3,13-triazatricyclo[13.2.0.0~4,6~]heptadec-7-ene-4-carboxamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • hepatitis c virus (isolate 1)
KeywordsHYDROLASE / Structure-based design / HCV NS3/4A serine protease / azetidine inhibitors / PROTEROS BIOSTRUCTURES GMBH

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