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Title2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1d/e.
Journal, issue, pagesAmino Acids, Vol. 43, Page 1577-1591, Year 2012
Publish dateJun 30, 2014 (structure data deposition date)
AuthorsBischof, J. / Leban, J. / Zaja, M. / Grothey, A. / Radunsky, B. / Othersen, O. / Strobl, S. / Vitt, D. / Knippschild, U.
External linksAmino Acids / PubMed:22331384
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-4twc:
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4- carboxamide derivatives as potent inhibitors of CK1d/e
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-37J:
2-{[2-(trifluoromethoxy)benzoyl]amino}-N-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1,3-thiazole-4-carboxamide

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CK1d / CK1e / Phosphorylation / Small molecule inhibitor

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