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TitleDifluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 7933-7946, Year 2014
Publish dateJun 30, 2014 (structure data deposition date)
AuthorsRichter, J. / Bischof, J. / Zaja, M. / Kohlhof, H. / Othersen, O. / Vitt, D. / Alscher, V. / Pospiech, I. / Garcia-Reyes, B. / Berg, S. ...Richter, J. / Bischof, J. / Zaja, M. / Kohlhof, H. / Othersen, O. / Vitt, D. / Alscher, V. / Pospiech, I. / Garcia-Reyes, B. / Berg, S. / Leban, J. / Knippschild, U.
External linksJ. Med. Chem. / PubMed:25191940
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4tw9:
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HSJ:
octyl beta-L-talopyranoside

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-386:
N-(2,2-difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-{[2-(trifluoromethoxy)benzoyl]amino}-1,3-thiazole-4-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CK1delta / CK1epsilon / phosphorylation / small molecule inhibitor

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