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TitleAminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Journal, issue, pagesSci Rep, Vol. 5, Page 13160-13160, Year 2015
Publish dateJun 23, 2014 (structure data deposition date)
AuthorsMirando, A.C. / Fang, P. / Williams, T.F. / Baldor, L.C. / Howe, A.K. / Ebert, A.M. / Wilkinson, B. / Lounsbury, K.M. / Guo, M. / Francklyn, C.S.
External linksSci Rep / PubMed:26271225
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-4ttv:
Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-BC9:
(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE/ANTIBIOTIC / tRNA / synthetase / inhibitor / macrolide / LIGASE-ANTIBIOTIC complex

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