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-Structure paper
Title | Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 3117-3130, Year 2015 |
Publish date | Jun 2, 2014 (structure data deposition date) |
![]() | Witschel, M.C. / Rottmann, M. / Schwab, A. / Leartsakulpanich, U. / Chitnumsub, P. / Seet, M. / Tonazzi, S. / Schwertz, G. / Stelzer, F. / Mietzner, T. ...Witschel, M.C. / Rottmann, M. / Schwab, A. / Leartsakulpanich, U. / Chitnumsub, P. / Seet, M. / Tonazzi, S. / Schwertz, G. / Stelzer, F. / Mietzner, T. / McNamara, C. / Thater, F. / Freymond, C. / Jaruwat, A. / Pinthong, C. / Riangrungroj, P. / Oufir, M. / Hamburger, M. / Maser, P. / Sanz-Alonso, L.M. / Charman, S. / Wittlin, S. / Yuthavong, Y. / Chaiyen, P. / Diederich, F. |
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Methods | X-ray diffraction |
Resolution | 2.2 - 2.7 Å |
Structure data | ![]() PDB-4tmr: ![]() PDB-4tn4: |
Chemicals | ![]() ChemComp-PLG: ![]() ChemComp-99S: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-BME: ![]() ChemComp-33G: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / alpha and beta protein / Transferase / methyltransferase activity / Inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |