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-Structure paper
Title | Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. |
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Journal, issue, pages | J. Mol. Biol., Vol. 427, Page 924-942, Year 2015 |
Publish date | Jan 5, 2015 (structure data deposition date) |
![]() | Khan, J.A. / Camac, D.M. / Low, S. / Tebben, A.J. / Wensel, D.L. / Wright, M.C. / Su, J. / Jenny, V. / Gupta, R.D. / Ruzanov, M. ...Khan, J.A. / Camac, D.M. / Low, S. / Tebben, A.J. / Wensel, D.L. / Wright, M.C. / Su, J. / Jenny, V. / Gupta, R.D. / Ruzanov, M. / Russo, K.A. / Bell, A. / An, Y. / Bryson, J.W. / Gao, M. / Gambhire, P. / Baldwin, E.T. / Gardner, D. / Cavallaro, C.L. / Duncia, J.V. / Hynes, J. |
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Methods | X-ray diffraction |
Resolution | 2.4 - 3.14 Å |
Structure data | ![]() PDB-4s0s: ![]() PDB-4s0t: ![]() PDB-4xhd: |
Chemicals | ![]() ChemComp-40U: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | IMMUNE SYSTEM / pregnane X receptor / PXR / ligand binding domain / steroid receptor coactivator-1; CCR1 / Chemokine Receptor-1; NR / nuclear receptor; AF / activation function; CYP / cytochrome P450; MDR1 / multi-drug resistance gene-1 / TRANSCRIPTION / NUCLEAR RECEPTOR / MULTIPLE BINDING MODES / XENOBIOTIC / PROMISCUOUS / NUCLEAR HORMONE RECEPTOR / Chemokine Receptor-1; Adnectin NR / multi-drug resistance gene-1. |