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TitleThe Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Journal, issue, pagesStructure, Vol. 23, Page 851-862, Year 2015
Publish dateDec 5, 2014 (structure data deposition date)
AuthorsLohofener, J. / Steinke, N. / Kay-Fedorov, P. / Baruch, P. / Nikulin, A. / Tishchenko, S. / Manstein, D.J. / Fedorov, R.
External linksStructure / PubMed:25892109
MethodsX-ray diffraction
Resolution2 - 3.1 Å
Structure data

PDB-4rwn:
Crystal structure of the pre-reactive state of porcine OAS1
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4rwo:
Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4rwp:
Crystal structure of porcine OAS1 in complex with dsRNA
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-4rwq:
Crystal structure of the apo-state of porcine OAS1
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-APC:
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER / AMP-CPP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
  • synthetic construct (others)
KeywordsTRANSFERASE/RNA / Innate immunity / pathogen RNA sensor / Interferon-induced / dsRNA-activated / TRANSFERASE-RNA complex / TRANSFERASE

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