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TitleDiscovery of 2-pyridylureas as glucokinase activators.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 8180-8186, Year 2014
Publish dateSep 16, 2014 (structure data deposition date)
AuthorsHinklin, R.J. / Aicher, T.D. / Anderson, D.A. / Baer, B.R. / Boyd, S.A. / Condroski, K.R. / DeWolf, W.E. / Kraser, C.F. / McVean, M. / Rhodes, S.P. ...Hinklin, R.J. / Aicher, T.D. / Anderson, D.A. / Baer, B.R. / Boyd, S.A. / Condroski, K.R. / DeWolf, W.E. / Kraser, C.F. / McVean, M. / Rhodes, S.P. / Sturgis, H.L. / Voegtli, W.C. / Williams, L. / Houze, J.B.
External linksJ. Med. Chem. / PubMed:25203462
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4rch:
Discovery of 2-Pyridyl Ureas as Glucokinase Activators
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-3LZ:
1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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