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-Structure paper
Title | Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9796-9810, Year 2014 |
Publish date | Sep 15, 2014 (structure data deposition date) |
![]() | Epstein, O. / Bryan, M.C. / Cheng, A.C. / Derakhchan, K. / Dineen, T.A. / Hickman, D. / Hua, Z. / Human, J.B. / Kreiman, C. / Marx, I.E. ...Epstein, O. / Bryan, M.C. / Cheng, A.C. / Derakhchan, K. / Dineen, T.A. / Hickman, D. / Hua, Z. / Human, J.B. / Kreiman, C. / Marx, I.E. / Weiss, M.M. / Wahl, R.C. / Wen, P.H. / Whittington, D.A. / Wood, S. / Zheng, X.M. / Fremeau, R.T. / White, R.D. / Patel, V.F. |
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Methods | X-ray diffraction |
Resolution | 1.78 - 2.4 Å |
Structure data | ![]() PDB-4rce: ![]() PDB-4rcf: |
Chemicals | ![]() ChemComp-3LN: ![]() ChemComp-IOD: ![]() ChemComp-HOH: ![]() ChemComp-3LO: ![]() ChemComp-GOL: |
Source |
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![]() | Hydrolase/Hydrolase inhibitor / aspartic protease / Alzheimer's disease / APP / amyloid precursor protein / brain / Hydrolase-Hydrolase inhibitor complex |