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Structure paper

TitleStructure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
Journal, issue, pagesN Engl J Med, Vol. 373, Page 428-437, Year 2015
Publish dateAug 27, 2014 (structure data deposition date)
AuthorsTap, W.D. / Wainberg, Z.A. / Anthony, S.P. / Ibrahim, P.N. / Zhang, C. / Healey, J.H. / Chmielowski, B. / Staddon, A.P. / Cohn, A.L. / Shapiro, G.I. ...Tap, W.D. / Wainberg, Z.A. / Anthony, S.P. / Ibrahim, P.N. / Zhang, C. / Healey, J.H. / Chmielowski, B. / Staddon, A.P. / Cohn, A.L. / Shapiro, G.I. / Keedy, V.L. / Singh, A.S. / Puzanov, I. / Kwak, E.L. / Wagner, A.J. / Von Hoff, D.D. / Weiss, G.J. / Ramanathan, R.K. / Zhang, J. / Habets, G. / Zhang, Y. / Burton, E.A. / Visor, G. / Sanftner, L. / Severson, P. / Nguyen, H. / Kim, M.J. / Marimuthu, A. / Tsang, G. / Shellooe, R. / Gee, C. / West, B.L. / Hirth, P. / Nolop, K. / van de Rijn, M. / Hsu, H.H. / Peterfy, C. / Lin, P.S. / Tong-Starksen, S. / Bollag, G.
External linksN Engl J Med / PubMed:26222558
MethodsX-ray diffraction
Resolution2.75 - 2.8001 Å
Structure data

PDB-4r7h:
Crystal structure of FMS KINASE domain with a small molecular inhibitor, PLX3397
Method: X-RAY DIFFRACTION / Resolution: 2.8001 Å

PDB-4r7i:
Crystal structure of FMS kinase domain with a small molecular inhibitor, GLEEVEC
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-P31:
5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine / inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / CSF-1-R / FMS proto-oncogene / C-FMS / CD115 antigen / kinase / ATP-binding / PLX3397 / transferase-transferase inhibitor complex / GLEEVEC

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