| タイトル | Toll-like receptor 8 senses degradation products of single-stranded RNA |
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| ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Vol. 22, Page 109-115, Year 2015 |
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| 掲載日 | 2014年7月30日 (構造データの登録日) |
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著者 | Tanji, H. / Ohto, U. / Shibata, T. / Taoka, M. / Yamauchi, Y. / Isobe, T. / Miyake, K. / Shimizu, T. |
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リンク | Nat. Struct. Mol. Biol. / PubMed:25599397 |
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| 手法 | X線回折 |
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| 解像度 | 1.9 - 2.62 Å |
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| 構造データ | PDB-4r07: Crystal structure of human TLR8 in complex with ORN06 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4r08: Crystal structure of human TLR8 in complex with ssRNA40 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4r09: Crystal structure of human TLR8 in complex with ORN06S 手法: X-RAY DIFFRACTION / 解像度: 2.62 Å PDB-4r0a: Crystal structure of human TLR8 in complex with uridine mononucleoside 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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| 化合物 | ChemComp-UCG: 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate)
ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose
ChemComp-06S: O-[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-[(thiophosphonooxy)methyl]tetrahydrofuran-3-yl}oxy)(sulfanyl)phosphoryl]oxy}methyl)-4-hydroxytetrahydrofuran-3-yl] dihydrogen (S)-phosphorothioate
ChemComp-UPT: 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione
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| 由来 | homo sapiens (ヒト)
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キーワード | IMMUNE SYSTEM / Leucine rich repeat / Glycosylation / innate immunity / RNA recognition / RNA receptor / RNA binding / antiviral binding / antitumor drug binding / RNA / ssRNA |
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