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-Structure paper
Title | Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 3782-3785, Year 2014 |
Publish date | Jun 19, 2014 (structure data deposition date) |
Authors | Wang, Y. / Zhu, J. / Liu, J.J. / Chen, X. / Mihalic, J. / Deignan, J. / Yu, M. / Sun, D. / Kayser, F. / McGee, L.R. ...Wang, Y. / Zhu, J. / Liu, J.J. / Chen, X. / Mihalic, J. / Deignan, J. / Yu, M. / Sun, D. / Kayser, F. / McGee, L.R. / Lo, M.C. / Chen, A. / Zhou, J. / Ye, Q. / Huang, X. / Long, A.M. / Yakowec, P. / Oliner, J.D. / Olson, S.H. / Medina, J.C. |
External links | Bioorg. Med. Chem. Lett. / PubMed:25042256 |
Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | PDB-4qoc: |
Chemicals | ChemComp-35T: ChemComp-HOH: |
Source |
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Keywords | Ligase/Ligase inhibitor / MDM2 / p53 / protein-protein interaction / inhibitor / Ligase-Ligase inhibitor complex |