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Structure paper

TitleThe tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 22, Page 672-678, Year 2015
Publish dateJun 12, 2014 (structure data deposition date)
AuthorsSun, J. / Siroy, A. / Lokareddy, R.K. / Speer, A. / Doornbos, K.S. / Cingolani, G. / Niederweis, M.
External linksNat. Struct. Mol. Biol. / PubMed:26237511
MethodsX-ray diffraction
Resolution1.1 Å
Structure data

PDB-4qlp:
Atomic structure of tuberculosis necrotizing toxin (TNT) complexed with its immunity factor IFT
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
Keywordshydrolase/protein binding / DUF4237 / NAD-binding domain / b-NAD+ glycohydrolase / factor Rv3902c renamed here as immunity factor of TNT / Membrane / hydrolase-protein binding complex

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