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Structure paper

TitlePharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia.
Journal, issue, pagesNat. Chem. Biol., Vol. 11, Page 571-578, Year 2015
Publish dateJun 10, 2014 (structure data deposition date)
AuthorsGrebien, F. / Vedadi, M. / Getlik, M. / Giambruno, R. / Grover, A. / Avellino, R. / Skucha, A. / Vittori, S. / Kuznetsova, E. / Smil, D. ...Grebien, F. / Vedadi, M. / Getlik, M. / Giambruno, R. / Grover, A. / Avellino, R. / Skucha, A. / Vittori, S. / Kuznetsova, E. / Smil, D. / Barsyte-Lovejoy, D. / Li, F. / Poda, G. / Schapira, M. / Wu, H. / Dong, A. / Senisterra, G. / Stukalov, A. / Huber, K.V. / Schonegger, A. / Marcellus, R. / Bilban, M. / Bock, C. / Brown, P.J. / Zuber, J. / Bennett, K.L. / Al-Awar, R. / Delwel, R. / Nerlov, C. / Arrowsmith, C.H. / Superti-Furga, G.
External linksNat. Chem. Biol. / PubMed:26167872
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-4ql1:
Crystal structure of human WDR5 in complex with compound OICR-9429
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-35Q:
N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

ChemComp-UNX:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / WDR5 / WD repeat domain 5 / OICR-9429 inhibitor / Structural Genomics / Structural Genomics Consortium / SGC / TRANSCRIPTION-INHIBITOR complex

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