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Structure paper

TitleFoot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage.
Journal, issue, pagesVirology, Vol. 468-470C, Page 397-408, Year 2014
Publish dateMay 7, 2014 (structure data deposition date)
AuthorsSteinberger, J. / Grishkovskaya, I. / Cencic, R. / Juliano, L. / Juliano, M.A. / Skern, T.
External linksVirology / PubMed:25240326
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-4qbb:
Structure of the foot-and-mouth disease virus leader proteinase in complex with inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4-CARBAMIMIDAMIDOBUTYL)AMINO]-4-METHYL-1-OXOPENTAN-2-YL}AMINO)-3-HYDROXY-4-OXOBUTANOYL]-L-ARGINYL-L-PROLINAMIDE)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-E69:
N~2~-[(3S)-4-({(2R)-1-[(4-carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}amino)-3-hydroxy-4-oxobutanoyl]-L-arginyl-L-prolinamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • foot-and-mouth disease virus
Keywordshydrolase/hydrolase inhibitor / Papain-like cysteine proteinase / hydrolase-hydrolase inhibitor complex

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