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-Structure paper
Title | Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9435-9446, Year 2014 |
Publish date | Mar 28, 2014 (structure data deposition date) |
Authors | Dudutiene, V. / Matuliene, J. / Smirnov, A. / Timm, D.D. / Zubriene, A. / Baranauskiene, L. / Morkunaite, V. / Smirnoviene, J. / Michailoviene, V. / Juozapaitiene, V. ...Dudutiene, V. / Matuliene, J. / Smirnov, A. / Timm, D.D. / Zubriene, A. / Baranauskiene, L. / Morkunaite, V. / Smirnoviene, J. / Michailoviene, V. / Juozapaitiene, V. / Mickeviciute, A. / Kazokaite, J. / Baksyte, S. / Kasiliauskaite, A. / Jachno, J. / Revuckiene, J. / Kisonaite, M. / Pilipuityte, V. / Ivanauskaite, E. / Milinaviciute, G. / Smirnovas, V. / Petrikaite, V. / Kairys, V. / Petrauskas, V. / Norvaisas, P. / Linge, D. / Gibieza, P. / Capkauskaite, E. / Zaksauskas, A. / Kazlauskas, E. / Manakova, E. / Grazulis, S. / Ladbury, J.E. / Matulis, D. |
External links | J. Med. Chem. / PubMed:25358084 |
Methods | X-ray diffraction |
Resolution | 1.06 - 2 Å |
Structure data | PDB-4pyx: PDB-4pyy: PDB-4pzh: PDB-4q06: PDB-4q07: PDB-4q08: PDB-4q09: PDB-4q0l: |
Chemicals | ChemComp-ZN: ChemComp-DMS: ChemComp-MES: ChemComp-V90: ChemComp-HOH: ChemComp-V14: ChemComp-EDO: ChemComp-BCN: ChemComp-V13: |
Source |
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Keywords | LYASE/LYASE INHIBITOR / drug design / carbonic anhydrase / benzenesulfonamide / metal-binding / lyase-lyase inhibitor complex / lyase-lyase inhibitor comple |