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Structure paper

TitleSyk inhibitors with high potency in presence of blood.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 24, Page 2278-2282, Year 2014
Publish dateMar 21, 2014 (structure data deposition date)
AuthorsThoma, G. / Blanz, J. / Buhlmayer, P. / Druckes, P. / Kittelmann, M. / Smith, A.B. / van Eis, M. / Vangrevelinghe, E. / Zerwes, H.G. / Che, J.J. ...Thoma, G. / Blanz, J. / Buhlmayer, P. / Druckes, P. / Kittelmann, M. / Smith, A.B. / van Eis, M. / Vangrevelinghe, E. / Zerwes, H.G. / Che, J.J. / He, X. / Jin, Y. / Lee, C.C. / Michellys, P.Y. / Uno, T. / Liu, H.
External linksBioorg. Med. Chem. Lett. / PubMed:24726806
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-4px6:
SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-2X6:
7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / kinase domain / phosphotransferase / transferase-transferase inhibitor complex

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