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-Structure paper
Title | Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding |
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Journal, issue, pages | To be Published |
Publish date | Mar 21, 2014 (structure data deposition date) |
![]() | Pennington, L.D. / Bartberger, M.D. / Croghan, M.D. / Andrews, K.L. / Ashton, K.S. / Bourbeau, M.P. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. |
![]() | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.15 - 2.2 Å |
Structure data | ![]() PDB-4px2: ![]() PDB-4px5: |
Chemicals | ![]() ChemComp-2WY: ![]() ChemComp-S6P: ![]() ChemComp-IOD: ![]() ChemComp-GOL: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-2WZ: |
Source |
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![]() | sugar binding protein/inhibitor / SIS domain containing protein / Regulatory protein - Binds to and inhibits Glucokinase / Glucokinase / sugar binding protein-inhibitor complex |