Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase.
Journal, issue, pages	J. Med. Chem., Vol. 57, Page 3856-3873, Year 2014
Publish date	Mar 14, 2014 (structure data deposition date)
Authors	Currie, K.S. / Kropf, J.E. / Lee, T. / Blomgren, P. / Xu, J. / Zhao, Z. / Gallion, S. / Whitney, J.A. / Maclin, D. / Lansdon, E.B. ...Currie, K.S. / Kropf, J.E. / Lee, T. / Blomgren, P. / Xu, J. / Zhao, Z. / Gallion, S. / Whitney, J.A. / Maclin, D. / Lansdon, E.B. / Maciejewski, P. / Rossi, A.M. / Rong, H. / Macaluso, J. / Barbosa, J. / Di Paolo, J.A. / Mitchell, S.A.
External links	J. Med. Chem. / PubMed:24779514
Methods	X-ray diffraction
Resolution	2 - 2.085 Å
Structure data	PDB-4puz: Crystal structure of spleen tyrosine kinase (Syk) in complex with GS-9973 Method: X-RAY DIFFRACTION / Resolution: 2.085 Å PDB-4pv0: Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor Method: X-RAY DIFFRACTION / Resolution: 2 Å
Chemicals	ChemComp-CG9: 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine ChemComp-HOH: WATER ChemComp-CG4: 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid ChemComp-CL: Unknown entry
Source	homo sapiens (human)
Keywords	TRANSFERASE/TRANSFERASE INHIBITOR / Syk / spleen tyrosine kinase / kinase inhibitor / Protein kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex