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Structure paper

TitleThe spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Journal, issue, pagesNucleic Acids Res., Vol. 42, Page 11233-11245, Year 2015
Publish dateMay 2, 2014 (structure data deposition date)
AuthorsKoag, M.C. / Nam, K. / Lee, S.
External linksNucleic Acids Res. / PubMed:25200079
MethodsX-ray diffraction
Resolution2.077 - 2.52 Å
Structure data

PDB-4pgq:
Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4pgx:
Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE
Method: X-RAY DIFFRACTION / Resolution: 2.077 Å

PDB-4pha:
Structure of human DNA polymerase beta complexed with A in the template base paired with incoming non-hydrolyzable CTP
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

PDB-4phd:
Structure of human DNA polymerase beta complexed with A in the template base paired with incoming non-hydrolyzable CTP and MANGANESE
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-1FZ:
5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-0KX:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTransferase / Lyase/DNA / DNA polymerase / nucleotidyl synthesis / Lyase-DNA complex / human DNA polymerase / nucleotidyl synthtsis / human DNA polymerase beta

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