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Structure paper

TitleThe first step of peptide selection in antigen presentation by MHC class I molecules.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page 1505-1510, Year 2015
Publish dateMay 1, 2014 (structure data deposition date)
AuthorsGarstka, M.A. / Fish, A. / Celie, P.H. / Joosten, R.P. / Janssen, G.M. / Berlin, I. / Hoppes, R. / Stadnik, M. / Janssen, L. / Ovaa, H. ...Garstka, M.A. / Fish, A. / Celie, P.H. / Joosten, R.P. / Janssen, G.M. / Berlin, I. / Hoppes, R. / Stadnik, M. / Janssen, L. / Ovaa, H. / van Veelen, P.A. / Perrakis, A. / Neefjes, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:25605945
MethodsX-ray diffraction
Resolution2 - 2.8 Å
Structure data

PDB-4pg9:
MHC Class I in complex with Sendai virus nucleoprotein peptide FAPGNYPAL
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4pgb:
MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNWPAL
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4pgc:
MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGN(3,5-diiodotyrosine)PAL
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4pgd:
MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAF
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4pge:
MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAW
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • mus musculus (house mouse)
  • sendai virus
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM/PEPTIDE / IMMUNE SYSTEM / IMMUNOGLOBULIN DOMAIN / IMMUNE RESPONSE / IMMUNE SYSTEM-PEPTIDE complex

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