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TitleTriazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 9323-9342, Year 2014
Publish dateMar 27, 2014 (structure data deposition date)
AuthorsMenet, C.J. / Fletcher, S.R. / Van Lommen, G. / Geney, R. / Blanc, J. / Smits, K. / Jouannigot, N. / Deprez, P. / van der Aar, E.M. / Clement-Lacroix, P. ...Menet, C.J. / Fletcher, S.R. / Van Lommen, G. / Geney, R. / Blanc, J. / Smits, K. / Jouannigot, N. / Deprez, P. / van der Aar, E.M. / Clement-Lacroix, P. / Lepescheux, L. / Galien, R. / Vayssiere, B. / Nelles, L. / Christophe, T. / Brys, R. / Uhring, M. / Ciesielski, F. / Van Rompaey, L.
External linksJ. Med. Chem. / PubMed:25369270
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4p7e:
Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-2HB:
N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide / medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / JAK1 inhibitor / Triazolopyridine

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