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Structure paper

TitleTaxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page E2530-E2539, Year 2014
Publish dateFeb 23, 2014 (structure data deposition date)
AuthorsLiu, Y.L. / Lindert, S. / Zhu, W. / Wang, K. / McCammon, J.A. / Oldfield, E.
External linksProc. Natl. Acad. Sci. USA / PubMed:24927548
MethodsX-ray diffraction
Resolution2.4 - 2.5 Å
Structure data

PDB-4p0v:
Crystal structure of human farnesyl diphosphoate synthase in complex with zoledronate and taxodione
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4p0w:
Human farnesyl diphosphate synthase in complex with Arenarone and zoledronate
Method: X-RAY DIFFRACTION / Resolution: 2.406 Å

PDB-4p0x:
Human farnesyl diphosphate synthase in complex with Taxodione
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZOL:
ZOLEDRONIC ACID / medication*YM

ChemComp-1WO:
(5beta)-11-hydroxyabieta-7,9(11),13-triene-6,12-dione

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-1XH:
2-{[(1S,2R,4aS,8aR)-1,2,4a-trimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl}cyclohexa-2,5-diene-1,4-dione

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / Human / FPPS / Inhibitor / Complex / Synthase / transferase-transferase inhibitor complex / TRANSFERASE / Prenyl Synthase

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