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Structure paper

TitleSubdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 27966-27978, Year 2014
Publish dateFeb 20, 2014 (structure data deposition date)
AuthorsZhang, Z. / Wu, J. / Lin, W. / Wang, J. / Yan, H. / Zhao, W. / Ma, J. / Ding, J. / Zhang, P. / Zhao, G.P.
External linksJ. Biol. Chem. / PubMed:25128527
MethodsX-ray diffraction
Resolution2 - 2.2 Å
Structure data

PDB-4ov4:
Isopropylmalate synthase binding with ketoisovalerate
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4ov9:
Structure of isopropylmalate synthase binding with alpha-isopropylmalate
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-KIV:
3-METHYL-2-OXOBUTANOIC ACID

ChemComp-HOH:
WATER

ChemComp-VPM:
(2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid

Source
  • leptospira biflexa (bacteria)
KeywordsTRANSFERASE / alpha/beta Tim barrel

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