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-Structure paper
Title | Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. |
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Journal, issue, pages | Plos One, Vol. 9, Page e103638-e103638, Year 2014 |
Publish date | Feb 13, 2014 (structure data deposition date) |
Authors | Chamberlain, P. / Delker, S. / Pagarigan, B. / Mahmoudi, A. / Jackson, P. / Abbasian, M. / Muir, J. / Raheja, N. / Cathers, B. |
External links | Plos One / PubMed:25111382 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.6 Å |
Structure data | PDB-4otd: PDB-4otg: PDB-4oth: PDB-4oti: |
Chemicals | ChemComp-HOH: ChemComp-2V9: ChemComp-DRN: ChemComp-MI1: |
Source |
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Keywords | TRANSFERASE / PRK1 / PKN1 / Protein kinase C related kinase 1 / KINASE / Protein Kinase / ATP Binding / Phosphorylation / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |