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-Structure paper
Title | Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 5, Page 40-44, Year 2014 |
Publish date | Aug 12, 2013 (structure data deposition date) |
![]() | Zhang, Z. / Ojo, K.K. / Vidadala, R. / Huang, W. / Geiger, J.A. / Scheele, S. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Rivas, K. ...Zhang, Z. / Ojo, K.K. / Vidadala, R. / Huang, W. / Geiger, J.A. / Scheele, S. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Rivas, K. / Siddaramaiah, L.K. / Comess, K.M. / Robinson, K.P. / Merta, P.J. / Kifle, L. / Hol, W.G. / Parsons, M. / Merritt, E.A. / Maly, D.J. / Verlinde, C.L. / Van Voorhis, W.C. / Fan, E. |
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Methods | X-ray diffraction |
Resolution | 1.998 - 2.4 Å |
Structure data | ![]() PDB-4m84: ![]() PDB-4ona: |
Chemicals | ![]() ChemComp-21E: ![]() ChemComp-HOH: ![]() ChemComp-UW1: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / serine/threonine protein kinase / transferase / calcium-binding / ATP-binding / bumped kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |