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Structure paper

TitleStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 8025-8030, Year 2014
Publish dateJan 23, 2014 (structure data deposition date)
AuthorsLupardus, P.J. / Ultsch, M. / Wallweber, H. / Bir Kohli, P. / Johnson, A.R. / Eigenbrot, C.
External linksProc. Natl. Acad. Sci. USA / PubMed:24843152
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-4oli:
The pseudokinase/kinase protein from JAK-family member TYK2
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-2TT:
2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein kinase / phospho-transfer

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