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-Structure paper
Title | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5949-5964, Year 2014 |
Publish date | Jan 23, 2014 (structure data deposition date) |
Authors | Hong, F.T. / Norman, M.H. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. / Jordan, S.R. / Lloyd, D.J. ...Hong, F.T. / Norman, M.H. / Ashton, K.S. / Bartberger, M.D. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. / Jordan, S.R. / Lloyd, D.J. / Sivits, G. / Tadesse, S. / Hale, C. / St Jean, D.J. |
External links | J. Med. Chem. / PubMed:25001129 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-4olh: |
Chemicals | ChemComp-2TO: ChemComp-S6P: ChemComp-IOD: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | CARBOHYDRATE BINDING PROTEIN / SIS domain / Regulatory Protein / binds to and inhibits Glucokinase / Glucokinase / Liver |