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Structure paper

TitleGE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Journal, issue, pagesElife, Vol. 3, Page e02450-e02450, Year 2014
Publish dateSep 16, 2013 (structure data deposition date)
AuthorsZhang, Y. / Degen, D. / Ho, M.X. / Sineva, E. / Ebright, K.Y. / Ebright, Y.W. / Mekler, V. / Vahedian-Movahed, H. / Feng, Y. / Yin, R. ...Zhang, Y. / Degen, D. / Ho, M.X. / Sineva, E. / Ebright, K.Y. / Ebright, Y.W. / Mekler, V. / Vahedian-Movahed, H. / Feng, Y. / Yin, R. / Tuske, S. / Irschik, H. / Jansen, R. / Maffioli, S. / Donadio, S. / Arnold, E. / Ebright, R.H.
External linksPubMed:24755292
MethodsX-ray diffraction
Resolution2.8 - 3.624 Å
Structure data

PDB-4mq9:
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077
Method: X-RAY DIFFRACTION / Resolution: 3.35 Å

PDB-4oin:
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4oio:
Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-4oip:
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-4oiq:
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin
Method: X-RAY DIFFRACTION / Resolution: 3.624 Å

PDB-4oir:
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
Method: X-RAY DIFFRACTION / Resolution: 3.105 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-MB8:
(2Z)-2-methylbut-2-enoic acid

ChemComp-HOH:
WATER

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-2TM:
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine

ChemComp-RFV:
rifamycin SV

Source
  • thermus thermophilus (bacteria)
  • actinomadura sp. (bacteria)
KeywordsTRANSCRIPTION / TRANSFERASE/ANTIBIOTIC / DNA-directed RNA polymerase / transferase-antibiotic complex / GE23077 / transcription inhibitor / transcription open complex / transcription initiation complex / i site / i+1 site / RNA polymerase / DNA/RNA/NTP binding / polymerization of ribonucleotides / nucleoid / TRANSFERASE / de novo transcription initiation / substrate complex / transcription initiation / CMPcPP / rifampicin / Rif / Rifampin / rifamycin SV

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