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Structure paper

TitleA natural-product switch for a dynamic protein interface.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 53, Page 6443-6448, Year 2014
Publish dateJan 8, 2014 (structure data deposition date)
AuthorsScheepstra, M. / Nieto, L. / Hirsch, A.K. / Fuchs, S. / Leysen, S. / Lam, C.V. / in het Panhuis, L. / van Boeckel, C.A. / Wienk, H. / Boelens, R. ...Scheepstra, M. / Nieto, L. / Hirsch, A.K. / Fuchs, S. / Leysen, S. / Lam, C.V. / in het Panhuis, L. / van Boeckel, C.A. / Wienk, H. / Boelens, R. / Ottmann, C. / Milroy, L.G. / Brunsveld, L.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:24821627
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-4oc7:
Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-2QO:
(2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / ligand binding domain

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