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Structure paper

TitleStructure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Journal, issue, pagesScience, Vol. 343, Page 1244-1248, Year 2014
Publish dateJan 6, 2014 (structure data deposition date)
AuthorsHan, Y. / Donovan, J. / Rath, S. / Whitney, G. / Chitrakar, A. / Korennykh, A.
External linksScience / PubMed:24578532
MethodsX-ray diffraction
Resolution2.1 - 2.6 Å
Structure data

PDB-4oau:
Complete human RNase L in complex with biological activators.
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4oav:
Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-PUP:
(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate

Source
  • homo sapiens (human)
KeywordsHYDROLASE/RNA / RNase L / RNASEL / 2-5A / 2' / 5'-oligoadenylate / interferon / KEN / pseudokinase / kinase / inflammation / Ire1 / RIDD / regulated RNA decay / splicing cleavage / HPC1 / hereditary prostate cancer 1 / RNase L kinase-homology and KEN domain-containing / innate immunity / interferon response / antiviral response / 2-5A (2' / 5'-linked oligoadenylate)and RNA / HYDROLASE-RNA complex / dsRNA / RNase / RNA decay / RNase L protein kinase / KEN-domain containing / innate immune response / dsRNA response / 5'-linked oligoadenylates; RNA

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